COAT 2
COAT™
Non-invasive
At-home Use
Clinically proven
The First Therapy Designed to Restore Brain Structure in Alzheimer's Disease.
Amyloid Is Gone. The Brain Is Still Declining.
Current Alzheimer's therapies clear plaque. They don't rebuild what's lost. No approved therapy today restores brain structure in early disease.
1 in 4
Patients on existing therapies experience serious brain swelling (ARIA)
$340K+
Cost per quality-adjusted life year — unsustainable for patients and payers
Zero
Approved therapies that restore brain structure in early Alzheimer's disease
Restores Brain Structure. Not Just Slows Decline.
COAT™ harnesses the power of smell — the direct gateway to the brain — to drive neuroplasticity and rebuild what Alzheimer’s destroys.
Targets Neuroplasticity
Stimulates the brain's natural ability to rewire and rebuild.
At-Home Treatment
Just 18 minutes a day. No clinic. No infusions.
Safe & Well Tolerated
No ARIA. No specialist required. Zero serious adverse events.
First Structural Restorer
The only therapy designed to grow back what Alzheimer's takes.
From Scent to Brain Restoration
COAT™ directly engages the olfactory–hippocampal pathway — the earliest site of degeneration in Alzheimer’s disease.
Deliver
Personalized odor pulses delivered through a nasal cannula via precision algorithm.
Engage
Activates olfactory memory circuits deep in the brain.
Rebuild
Strengthens synaptic connectivity and drives neuroplasticity.
Restore
Measurable improvements in brain volume and cognitive function.
Real Change in the Brain. Proven in a Controlled Trial.
In a randomized controlled trial in early Alzheimer’s and aMCI patients:
+2.34
PACC Score increase vs. control (p = 0.02)
92%
Treatment adherence rate in at-home use
0
Serious adverse events. No ARIA. No infusions. No hospital visits.
+2.6%
Gray matter volume increase in memory-critical brain regions
Featured by the National Institutes of Health
"It's empowering to know I am doing something to help my brain every day."
— COAT Trial Participant
