This is a 6-month-long study with a few visits to one of our facilities at the beginning of
the study, a 3-month follow-up visit, and a 6-month follow-up visit.
Participants will be using a new investigational at-home device that emits odors from
plant-based essential oils. This device was designed to help reduce opioid addiction.
Yes, study participation is voluntary and is compensated.
A clinical research study to evaluate and optimize the portable, home-based product, Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT), as an alternative strategy for relapse prevention in patients with Opioid Use (OUD) and other substance use disorders (SUD). The orbitofrontal cortex (OFC) plays important role in the regulation of addiction through the provision of an associative structure (i.e. cognitive map) for these mental simulations. Additionally, the OFC plays a critical role in emotion regulation through an enhanced cognitive reappraisal of negative affective cues; and negative affect is a strong predictor of substance relapse.
A clinical research study to evaluate and optimize the portable, home-based product, Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT), as an alternative strategy for relapse prevention in patients with Opioid Use (OUD) and other substance use disorders (SUD). The orbitofrontal cortex (OFC) plays important role in the regulation of addiction through the provision of an associative structure (i.e. cognitive map) for these mental simulations. Additionally, the OFC plays a critical role in emotion regulation through an enhanced cognitive reappraisal of negative affective cues; and negative affect is a strong predictor of substance relapse.
People with OUD have reduced OFC volume and function, and heroin and cocaine dose-dependently diminish OFC neuronal functions, thereby fueling recurrent drug use. The CBOT is a programmed, portable, safe, user-friendly device for conjoined chemosensory stimulation of OFC neural activity with stimulation parameters that overcome OFC desensitization, and for the administration of olfactory cognitive tasks that synergistically engage the OFC with high fidelity sufficient to induce lasting changes in OFC functions.